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京都大学ウイルス研究所生体応答学研究部門感染防御研究分野。竹内研究室です。

お問い合わせ先E-mail: otake @ virus.kyoto-u.ac.jp (@前後のスペースを外して下さい)
TEL: 075-751-4024

研究業績publication

原著論文


2013年

  1. Ma, J., Bang, B.R., Lu, J., Eun, S.Y., Otsuka, M., Croft, M., Tobias, P., Han, J., Takeuchi, O., Akira, S., Karin, M., Yagita, H., Kang, Y.J. (2013). The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci. Signal. 6, ra87.
  2. Maruyama, K., Uematsu, S., Kondo, T., Takeuchi, O., Martino, M.M., Kawasaki, T., Akira, S. (2013). Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210, 1947-1960.
  3. Lee, H., Komano, J., Saitoh, Y., Yamaoka, S., Kozaki, T., Misawa, T., Takahama, M., Satoh, T., Takeuchi, O., Yamamoto, N., Matsuura, Y., Saitoh, T., Akira, S. (2013). Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc. Natl. Acad. Sci. USA 110, 12379-12384.
  4. Kawashima, T., Kosaka, A., Yan, H., Guo, Z., Uchiyama, R., Fukui, R., Kaneko, D., Kumagai, Y., You, D.J., Carreras, J., Uematsu, S., Jang, M.H., Takeuchi, O., Kaisho, T., Akira, S., Miyake, K., Tsutsui, H., Saito, T., Nishimura, I., Tsuji, N.M. (2013). Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β. Immunity 38, 1187-1197.
  5. Masuda, K., Ripley, B., Nishimura, R., Mino, T., Takeuchi, O., Kiyonari, H., Shioi, G., Kishimoto, T. (2013). Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc. Natl. Acad. Sci. USA 110, 9409-9414.
  6. Uehata, T., Iwasaki, H., Vandenbon, Matsushita, K., Cuellar, E.H., Kuniyoshi, K., Satoh, T., Mino, T., Suzuki, Y., Standley, D.M., Tsujimura, T., Rakugi, H., Isaka, Y., Takeuchi, O., Akira, S. (2013). Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation. Cell 153, 1036-1049.
  7. Fukasaka, M., Ori, D., Kawagoe, T., Uematsu, S., Maruyama, K., Okazaki, T., Kozaki, T., Imamura, T., Tartey, S., Mino, T., Satoh, T., Akira, S., Takeuchi, O. (2013). Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation. J. Immunol. 190, 5702-5711.
  8. Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O., Akira, S. (2013). Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature 495, 524-528.
  9. Ori, D., Kato, H., Sanjo, H., Tartey, S., Mino, T., Akira, S., Takeuchi, O. (2013). Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J. Immunol. 190, 4037-4045.
  10. Sandig, H., Jobbings, C.E., Roldan, N.G., Whittingham-Dowd, J., Orinska, Z., Takeuchi, O., Akira, S., Bulfone-Paus, S. (2013). IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur. J. Immunol. 43, 979-988.

2012年

  1. Maruyama, K., Fukasaka, M., Vandenbon, A., Saitoh, T., Kawasaki, T., Kondo, T., Yokoyama, K.K., Kidoya, H., Takakura, N., Standley, D., Takeuchi, O., Akira, S. (2012). The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation. Immunity 37, 1024-1036.
  2. Maruyama, K., Kawagoe, T., Kondo, T., Akira, S.*, Takeuchi, O.* (*correspondence). (2012). TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. J. Biol. Chem. 287, 29114-29124.
  3. Abe, T., Fukuhara, T., Wen, X., Ninomiya, A., Moriishi, K., Maehara, Y., Takeuchi, O., Kawai, T., Akira, S., Matsuura, Y. (2012). CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan. J. Virol. 86, 6159-6170.
  4. Lee, K.G., Xu, S., Kang, Z.H., Huo, J., Huang, M., Liu, D., Takeuchi, O., Akira, S., Lam, K.P. (2012). Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc. Natl. Acad. Sci. USA 109, 5791-5796.
  5. Schuessler, A., Funk, A., Lazear, H.M., Cooper, D.A., Torres, S., Daffis, S., Jha, B.K., Kumagai, Y., Takeuchi, O., Hertzog, P., Silverman, R., Akira, S., Barton, D.J., Diamond, M.S., Khromykh, A.A. (2012). West Nile virus non-coding subgenomic RNA contributes to viral evasion of type I interferon-mediated antiviral response. J. Virol. 86, 5708-5718.
  6. Deshmukh, S.D., Muller, S., Hese, K., Rauch, K.S., Wennekamp, J., Takeuchi, O., Akira, S., Golenbock, D.T., Henneke, P. (2012). NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J. Immunol. 188, 774-780.
  7. Abe, Y., Fujii, K., Nagata, N., Takeuchi, O., Akira, S., Oshiumi, H., Matsumoto, M., Seya, T., Koike, S. (2012). The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice. J. Virol. 86, 185-194.

2011年

  1. Iwasaki, H., Takeuchi, O.*, Teraguchi, S., Matsushita, K., Uehata, T., Kuniyoshi, K., Satoh, T., Saitoh, T., Matsushita, M., Standley, D.M., Akira, S.* (*correspondence). (2011). The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat. Immunol. 12, 1167-1175.
  2. Clark, K., Takeuchi, O., Akira, S., Cohen, P. (2011). The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 108, 17093-17098.
  3. Saitoh, T., Satoh, T., Yamamoto, N., Uematsu, S., Takeuchi, O., Kawai, T., Akira, S. (2011). Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. Immunity 34, 352-363.
  4. Lee, P.Y., Kumagai, Y., Xu, Y., Li, Y., Barker, T., Liu, C., Sobel, E.S., Takeuchi, O., Akira, S., Satoh, M., Reeves, W.H. (2011). IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. J. Immunol. 186, 1747-1754.
  5. Joung, S.M., Park, Z.Y., Rani, S., Takeuchi, O., Akira, S., Lee, J.Y. (2011). Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J. Immunol. 186, 499-507.
  6. Matsumoto, K., Kan-O, K., Eguchi-Tsuda, M., Fukuyama, S., Asai, Y., Matsumoto, T., Moriwaki, A., Matsunaga, Y., Tsutsui, H., Kawai, T., Takeuchi, O., Akira, S., Yagita, H., Azuma, M., Nakanishi, Y., Inoue, H. (2011). Essential Role of B7-H1 in Double-stranded RNA-induced Augmentation of an Asthma Phenotype in Mice. Am. J. Respir. Cell Mol. Biol. 45, 31-39.

2010年

  1. Oshiumi, H., Ikeda, M., Matsumoto, M., Watanabe, A., Takeuchi, O., Akira, S., Kato, N., Shimotohno, K., Seya, T. (2010). Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS One 5, e14258.
  2. Ren, D., Tu, H.C., Kim, H., Wang, G.X., Bean, G.R., Takeuchi, O., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J., Cheng, E.H. (2010). BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 330, 1390-1393.
  3. Miyake, T., Satoh, T., Kato, H., Matsushit, K., Kumagai, Y., Vandenbon, A., Tani, T., Muta, T., Akira, S., Takeuchi, O. (2010). IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18. Proc. Natl. Acad. Sci. USA 107, 17680-17685.
  4. Hashiguchi, S., Yamaguchi, Y., Takeuchi, O., Akira, S., Sugimura, K. (2010). Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling. Biochem. Biophys. Res. Commun. 402, 19-22.
  5. *Satoh, T., *Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., Honma, K., Matsuyama, T., Yui, K., Tsujimura, T., Standley, D.M., Nakanishi, K., Nakai, K., Akira, S. (*Equal contribution). (2010). The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 11, 936-944.
  6. Arimoto, K., Funami, K., Saeki, Y., Tanaka, K., Okawa, K., Takeuchi, O., Akira, S., Murakami, Y., Shimotohno, K. (2010). Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proc. Natl. Acad. Sci. USA 107, 15856-15861.
  7. Schulz, O., Pichlmair, A., Rehwinkel, J., Rogers, N.C., Scheuner, D., Kato, H., Takeuchi, O., Akira, S., Kaufman, R.J., Reis e Sousa, C. (2010). Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe. 7, 354-361.
  8. Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., Gohda, J., Inoue, J., Hayakawa, M. (2010). Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277, 2051-2066.
  9. Berger, M., Krebs, P., Crozat, K., Li, X., Croker, B.A., Siggs, O.M., Popkin, D., Du, X., Lawson, B.R, Theofilopoulos, A.N., Xia, Y., Khovananth, K.Y., Moresco, E.M., Satoh, T., Takeuchi, O., Akira, S., Beutler, B. (2010). An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat. Immunol. 11, 335-343.
  10. Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., Takeuchi, O. (2010). LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc. Natl. Acad. Sci. USA 107, 1512-1517.
  11. Kirsch, D.G., Santiago, P.M., di Tomaso, E., Sullivan, J.M., Hou, W.S., Dayton, T., Jeffords, L.B., Sodha, P., Mercer, K.L., Cohen, R., Takeuchi, O., Korsmeyer, S.J., Bronson, R.T., Kim, C.F., Haigis, K.M., Jain, R.K., Jacks, T. (2010). p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327, 593-596.
  12. Tseng, P.-H., Matsuzawa, A., Zhang, W., Mino, T., Vignali, D.A.A., Karin, M. (2010). Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat. Immunol. 11, 70-75.

2009年

  1. Ishikawa, E., Ishikawa, T., Morita, Y.S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., Yamasaki, S. (2009). Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 206, 2879-2888.
  2. Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., Yamamoto, N., Kawai, T., Ishii, K., Takeuchi, O., Yoshimori, T., Akira, S. (2009). Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc. Natl. Acad. Sci. USA 106, 20842-20846.
  3. Kim, H., Tu, H.C., Ren, D., Takeuchi, O., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J., Cheng, E.H. (2009). Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol. Cell. 36, 487-499.
  4. Choi, M.K., Wang, Z., Ban, T., Yanai, H., Lu, Y., Koshiba, R., Nakaima, Y., Hangai, S., Savitsky, D., Nakasato, M., Negishi, H., Takeuch,i O., Honda, K., Akira, S., Tamura, T., Taniguchi, T. (2009). A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc. Natl. Acad. Sci. USA 106, 17870-17875.
  5. *Kawagoe, T., *Takeuchi, O., Takabatake, Y., Kato, H., Isaka, Y., Tsujimura, T., Akira, S. (*Equal contribution). (2009). TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat. Immunol.10, 965-972.
  6. Pichlmair, A., Schulz, O., Tan, C.P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., Reis e Sousa. C. (2009). Activation of MDA5 requires higher-order RNA structures generated during virus infection. J. Virol. 83, 10761-10769.
  7. Miyake, T., Kumagai, Y., Kato, H., Guo, Z., Matsushita, K., Satoh, T., Kawagoe, T., Kumar, H., Jang, M.H., Kawai, T., Tani, T., Takeuchi, O., Akira, S. (2009). Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. J. Immunol. 183, 2522-2528.
  8. Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G., Juranek, S., Kato, H., Kawai, T., Poeck, H., Fitzgerald, K.A., Takeuchi, O., Akira, S., Tuschl, T., Latz, E., Ludwig, J., Hartmann, G. (2009). Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31, 25-34.
  9. Konno, H., Yamamoto, T., Yamazaki, K., Gohda, J., Akiyama, T., Semba, K., Goto, H., Kato, A., Yujiri, T., Imai, T., Kawaguchi, Y., Su, B., Takeuchi, O., Akira, S., Tsunetsugu-Yokota, Y., Inoue, J. (2009). TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA. PLoS One 4, e5674.
  10. Abe, T., Kaname, Y., Wen, X., Tani, H., Moriishi, K., Uematsu, S., Takeuchi, O., Ishii, K.J., Kawai, T., Akira, S., Matsuura, Y. (2009). Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner. J. Virol. 83, 7629-7640.
  11. *Matsushita, K., *Takeuchi, O., Standley, D.M., Kumagai, Y., Kawagoe, T., Miyake, T., Satoh, T., Kato, H., Tsujimura, T., Nakamura, H., Akira, S. (*Equal contribution). (2009). Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458, 1185-1190.
  12. Kumagai, Y., Kumar, H., Koyama, S., Kawai, T., Takeuchi, O., Akira, S. (2009). Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells. J. Immunol. 182, 3960-3964.
  13. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., Saito, T. (2009). C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA 106, 1897-1902.
  14. Kurokawa, K., Lee, H., Roh, K.B., Asanuma, M., Kim, Y.S., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, H.J., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K., Lee, B.L. (2009). The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2. J. Biol. Chem. 284, 8406-8411.
  15. Steimer, D.A., Boyd, K., Takeuchi, O., Fisher, J.K., Zambetti, G.P., Opferman, J.T. (2009). Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113, 2805-2815.
  16. Mino, T., Aoyama, Y., Sera, T. (2009). Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer. J. Biotechnol. 140, 156-161.

2008年以前

こちら

総説など

  1. Mino, T., Takeuchi, O. (2013). Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation. Biotechnol. Genet. Eng. Rev. 29, 49-60.
  2. Takeuchi, O. (2012). IRF3: a molecular switch in pathogen responses. Nat. Immunol. 13, 634-635.
  3. Takeuch, O., Akira, S. (2011). Epigenetic control of macrophage polarization. Eur. J. Immunol. 41, 2490-2493.
  4. Takeuchi, O., Akira, S. (2010). Pattern recognition receptors and inflammation. Cell 140, 805-820.
  5. Takeuchi, O., Akira, S. (2009). Innate immunity to virus infection. Immunol. Rev.227, 75-86.
  6. Takeuchi, O., Akira, S. (2008). RIG-I-like antiviral protein in flies. Nat. Immunol. 9, 1327-1328.
  7. Kumagai, Y., Takeuchi, O., Akira, S. (2008). Pathogen recognition by innate receptors. J. Infect. Chemother.14, 86-92.
  8. Takeuchi, O., Akira, S. (2008). MDA5/RIG-I and virus recognition. Curr. Opin. Immunol. 20, 17-22.
  9. Kumagai, Y., Takeuchi, O., Akira, S. (2008). TLR9 as a key receptor for the recognition of DNA. Adv. Drug Deliv. Rev. 60, 795-804.
  10. Takeuchi, O., Akira, S. (2007). Signaling pathways activated by microorganisms. Curr. Opin. Cell Biol. 19, 185-191.
  11. Akira, S., Uematsu, S., Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell 124, 783-801.
  12. Takeuchi, O., Hemmi, H., Akira, S. (2004). Interferon response induced by Toll-like receptor signaling. J. Endotoxin Res. 10, 252-256.
  13. Takeda, K., Takeuchi, O., Akira, S. (2002). Recognition of lipopeptides by Toll-like receptors. J. Endotoxin Res.8, 459-463.
  14. Takeuchi, O., Akira, S. (2002). MyD88 as a bottle neck in Toll/IL-1 signaling. Curr. Top Microbiol. Immunol.270, 155-167.
  15. Takeuchi, O., Akira, S. (2002). Genetic approaches to the study of Toll-like receptor function. Microbes Infect. 4, 887-895.
  16. Takeuchi, O., Akira, S. (2001). Toll-like receptors; their physiological role and signal transduction system. Int. Immunopharmacol. 1, 625-635.

Takeuchi Lab.竹内研究室

〒606-8507
京都市左京区聖護院川原町53
京都大学ウイルス研究所
本館508号室
生体応答学研究部門
感染防御研究分野
E-mail:
otake @ virus.kyoto-u.ac.jp
(@前後のスペースを除いて下さい)
TEL: 075-751-4024
FAX: 075-761-5766


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